Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality.

ABSTRACT:

Aims

Inflammation plays an important role in cardiovascular disease (CVD) development. The NOD-like receptor protein-3 (NLRP3) inflammasome contributes to the development of atherosclerosis in animal models. Components of the NLRP3 inflammasome pathway such as interleukin-1β can therapeutically be targeted. Associations of genetically determined inflammasome-mediated systemic inflammation with CVD and mortality in humans are unknown.

Methods and results

We explored the association of genetic NLRP3 variants with prevalent CVD and cardiovascular mortality in 538 167 subjects on the individual participant level in an explorative gene-centric approach without performing multiple testing. Functional relevance of single-nucleotide polymorphisms on NLRP3 inflammasome activation has

SUBMITTER: Schunk SJ 

PROVIDER: S-EPMC8244638 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature