Identification and characterization of key long non-coding RNAs in the mouse cochlea.

ABSTRACT: The auditory system is a complex sensory network with an orchestrated multilayer regulatory programme governing its development and maintenance. Accumulating evidence has implicated long non-coding RNAs (lncRNAs) as important regulators in numerous systems, as well as in pathological pathways. However, their function in the auditory system has yet to be explored. Using a set of specific criteria, we selected four lncRNAs expressed in the mouse cochlea, which are conserved in the human transcriptome and are relevant for inner ear function. Bioinformatic characterization demonstrated a lack of coding potential and an absence of evolutionary conservation that represent properties commonly shared by their class members. RNAscope®  analysis of the spatial and temporal expression profiles reveal

SUBMITTER: Koffler-Brill T 

PROVIDER: S-EPMC8244781 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature