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Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution.

ABSTRACT: We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.

SUBMITTER: Monrad I

PROVIDER: S-EPMC8244814 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution.

Monrad Ida I Sahlertz Signe Risgaard SR Nielsen Stine Sofie Frank SSF Pedersen Louise Ørnskov LØ Petersen Mikkel Steen MS Kobel Carl Mathias CM Tarpgaard Irene Harder IH Storgaard Merete M Mortensen Klaus Leth KL Schleimann Mariane H MH Tolstrup Martin M Vibholm Line K LK

Open forum infectious diseases 20210604 7

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment. ...[more]

PMID: 34258320

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