Development of type 2 diabetes and insulin resistance in people with HIV infection: Prevalence, incidence and associated factors.

ABSTRACT:

Background

Diabetes and insulin resistance is an emerging issue in people with HIV. HIV-related mortality and morbidities have decreased markedly over the last few decades, while co-morbidities including type 2 diabetes (T2D) have increased.

Setting

This study investigated the incidence of T2D and insulin resistance in a cohort of HIV-patients on effective treatment.

Methods

Prevalence and baseline predictors of T2D were assessed in a cohort of 570 HIV-positive patients 50 years or older. Patients without diabetes (n = 505) were followed prospectively over a median period of 7.25 year (2012-2020) until T2D development, death or end of the study. T2D was defined as repeated fasting glucose values ≥7.0 mmol/L. Insulin resistance was defined as HOMA-IR ≥3.0. Predictors o

SUBMITTER: Bratt G 

PROVIDER: S-EPMC8244855 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature