Anticholinergic burden: First comprehensive analysis using claims data shows large variation by age and sex.

ABSTRACT:

Purpose

The cumulative effect of medication inhibiting acetylcholine activity-also known as anticholinergic burden (AB)-can lead to functional and cognitive decline, falls, and death. Given that studies on the population prevalence of AB are rare, we aimed to describe it in a large and unselected population sample.

Methods

Using the German Pharmacoepidemiological Research Database (GePaRD) with claims data from ~20% of the German population we analyzed outpatient drug dispensations in 2016. Based on the Anticholinergic Cognitive Burden (ACB) scale, we classified persons into four categories and determined the cumulative AB as continuous variable.

Results

Among 16,470,946 persons (54% female), the prevalence of clinically relevant AB (ACB≥3) was 10% (women) and 7% (men

SUBMITTER: Reinold J 

PROVIDER: S-EPMC8244868 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature