NLRP3 Regulates IL-4 Expression in TOX⁺ CD4⁺ T Cells of Cutaneous T Cell Lymphoma to Potentially Promote Disease Progression.

ABSTRACT: In cutaneous T cell lymphoma (CTCL), a dominant Th2 profile associated with disease progression has been proposed. Moreover, although the production and regulation of IL-4 expression during the early stages of the disease may have important implications in later stages, these processes are poorly understood. Here, we demonstrate the presence of TOX⁺ CD4⁺ T cells that produce IL-4⁺ in early-stage skin lesions of CTCL patients and reveal a complex mechanism by which the NLRP3 receptor promotes a Th2 response by controlling IL-4 production. Unassembled NLRP3 is able to translocate to the nucleus of malignant CD4⁺ T cells, where it binds to the human il-4 promoter. Accordingly, IL-4 expression is decreased by knocking down and increased by pro

SUBMITTER: Huanosta-Murillo E 

PROVIDER: S-EPMC8244903 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature