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Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration.


ABSTRACT: Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.

SUBMITTER: Rootring E 

PROVIDER: S-EPMC8244954 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration.

Rootring Ellen E   Sargel Cheryl L CL   Tobias Joseph D JD  

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20210628 5


Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The p  ...[more]

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