Perioperative Complications After Proctectomy for Rectal Cancer: Does Neoadjuvant Regimen Matter?

ABSTRACT:

Objective

Investigate the association between neoadjuvant treatment strategy and perioperative complications in patients undergoing proctectomy for nonmetastatic rectal cancer.

Summary of background data

Neoadjuvant SC-TNT is an alternative to neoadjuvant CRT for rectal cancer. Some have argued that short-course radiation and extended radiation-to-surgery intervals increase operative difficulty and complication risk. However, the association between SC-TNT and surgical complications has not been previously investigated.

Methods

This single-center retrospective cohort study included patients undergoing total mesorectal excision for nonmetastatic rectal cancer after SC-TNT or CRT between 2010 and 2018. Univariate analysis of severe POM and multiple secondary outcomes, i

SUBMITTER: Bauer PS 

PROVIDER: S-EPMC8245013 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature