Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure.

ABSTRACT:

Objectives

We hypothesize that elevated soluble suppression of tumorigenicity-2 concentrations, a marker of pulmonary epithelial injury, reflect ongoing lung injury in acute hypoxemic respiratory failure due to coronavirus disease 2019 and associate with continued ventilator dependence.

Design

We associated serial plasma soluble suppression of tumorigenicity-2 levels and markers of systemic inflammation including d-dimer, C-reactive protein, and erythrocyte sedimentation rate with 30-day mortality and ventilator dependence.

Setting

Adult medical ICUs and general medicine wards at an academic teaching hospital in Boston, MA.

Patients

Adult patients with severe acute respiratory syndrome coronavirus 2 infection and acute hypoxemic respiratory failure admitted to

SUBMITTER: Alladina JW 

PROVIDER: S-EPMC8245109 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature