BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52.

ABSTRACT: Strong connections exist between R-loops (three-stranded structures harbouring an RNA:DNA hybrid and a displaced single-strand DNA), genome instability and human disease^1-5. Indeed, R-loops are favoured in relevant genomic regions as regulators of certain physiological processes through which homeostasis is typically maintained. For example, transcription termination pause sites regulated by R-loops can induce the synthesis of antisense transcripts that enable the formation of local, RNA interference (RNAi)-driven heterochromation⁶. Pause sites are also protected against endogenous single-stranded DNA breaks by BRCA1⁷. Hypotheses about how DNA repair is enacted at pause sites include a role for RNA, which is emerging as a normal, albeit unexplained, regulat

SUBMITTER: Hatchi E 

PROVIDER: S-EPMC8245199 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature