Assessment of common infections and incident dementia using UK primary and secondary care data: a historical cohort study.

ABSTRACT:

Background

Common infections have been associated with dementia risk; however, evidence is scarce. We aimed to investigate the association between common infections and dementia in adults (≥65 years) in a UK population-based cohort study.

Methods

We did a historical cohort study of individuals who were 65 years and older with no history of dementia or cognitive impairment using the Clinical Practice Research Datalink linked to Hospital Episode Statistics between Jan 1, 2004, and Dec 31, 2018. Multivariable Cox proportional hazard regression models were used to estimate the association between time-updated previous common infections (sepsis, pneumonia, other lower respiratory tract infections, urinary tract infections, and skin and soft tissue infections) and incident dementi

SUBMITTER: Muzambi R 

PROVIDER: S-EPMC8245326 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature