HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling.

ABSTRACT:

Aims/hypothesis

Adipocytes are critical cornerstones of energy metabolism. While obesity-induced adipocyte dysfunction is associated with insulin resistance and systemic metabolic disturbances, adipogenesis, the formation of new adipocytes and healthy adipose tissue expansion are associated with metabolic benefits. Understanding the molecular mechanisms governing adipogenesis is of great clinical potential to efficiently restore metabolic health in obesity. Here we investigate the role of heart and neural crest derivatives-expressed 2 (HAND2) in adipogenesis.

Methods

Human white adipose tissue (WAT) was collected from two cross-sectional studies of 318 and 96 individuals. In vitro, for mechanistic experiments we used primary adipocytes from humans and mice as well as human m

SUBMITTER: Giroud M 

PROVIDER: S-EPMC8245394 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature