Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development.

ABSTRACT: The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful pregnancy. Although studies have shown that myeloid-derived suppressor cells (MDSCs) play an important role in maintaining feto-maternal tolerance, little is known about the role of MDSCs in pregnancies with intrauterine growth retardation (IUGR). Here, we reported that the activation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) during pregnancy was closely associated with fetal growth. In humans, class E scavenger receptor 1 (SR-E1), a distinct marker for human PMN-MDSCs, was used to investigate PMN-MDSC function during pregnancy. Continuous activation of SR-E1⁺ PMN-MDSCs was observed in all stages of pregnancy, accompanied by high cellular levels

SUBMITTER: Shi M 

PROVIDER: S-EPMC8245399 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature