Identification of subtypes of anticancer peptides based on sequential features and physicochemical properties.

ABSTRACT: Anticancer peptides (ACPs) are a kind of bioactive peptides which could be used as a novel type of anticancer drug that has several advantages over chemistry-based drug, including high specificity, strong tumor penetration capacity, and low toxicity to normal cells. As the number of experimentally verified bioactive peptides has increased significantly, various of in silico approaches are imperative for investigating the characteristics of ACPs. However, the lack of methods for investigating the differences in physicochemical properties of ACPs. In this study, we compared the N- and C-terminal amino acid composition for each peptide, there are three major subtypes of ACPs that are defined based on the distribution of positively charged residues. For the first time, we were motivated to dev

SUBMITTER: Huang KY 

PROVIDER: S-EPMC8245499 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature