Different cholinergic cell groups in the basal forebrain regulate social interaction and social recognition memory.

ABSTRACT: Social behaviour is a complex construct that is reported to include several components of social approach, interaction and recognition memory. Alzheimer's disease (AD) is mainly characterized by progressive dementia and is accompanied by cognitive impairments, including a decline in social ability. The cholinergic system is a potential constituent for the neural mechanisms underlying social behaviour, and impaired social ability in AD may have a cholinergic basis. However, the involvement of cholinergic function in social behaviour has not yet been fully understood. Here, we performed a selective elimination of cholinergic cell groups in the basal forebrain in mice to examine the role of cholinergic function in social interaction and social recognition memory by using the three-chamber tes

SUBMITTER: Okada K 

PROVIDER: S-EPMC8245640 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature