Remission Induced by TNF Inhibitors Plus Methotrexate is Associated With Changes in Peripheral Naive B Cells in Patients With Rheumatoid Arthritis.

ABSTRACT: Biological therapies, such as TNF inhibitors (TNFi), are increasing remission (REM) rates in rheumatoid arthritis (RA) patients, although these are still limited. The aim of our study was to analyze changes in the profile of peripheral blood mononuclear cells (PBMC) in patients with RA treated with TNFi in relation to the clinical response. This is a prospective and observational study including 78 RA patients starting the first TNFi. PBMC were analyzed by flow cytometry both at baseline and at 6 months. Disease activity at the same time points was assessed by DAS28, establishing DAS28 ≤ 2.6 as the criteria for REM. Logistic regression models were employed to analyze the association between the changes in PBMC and REM. After 6 months of TNFi treatment, 37% patients achieved REM by DAS28. P

SUBMITTER: Hernandez-Breijo B 

PROVIDER: S-EPMC8245775 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature