Pharmacokinetics of a Single Dose of Turmeric Curcuminoids Depends on Formulation: Results of a Human Crossover Study.

ABSTRACT:

Background

Curcuminoids from turmeric rhizome have significant health benefits but low bioavailability.

Objectives

To assess the pharmacokinetics of a novel natural turmeric dried colloidal suspension compared with 4 other turmeric formulations (including a standardized extract) at their respective recommended dosages.

Methods

Thirty healthy men and women (18 to 45 y old) were enrolled in a randomized, open-labeled, crossover trial, and sequentially consumed single oral doses of standard turmeric extract (1500 mg), liquid micellar preparation (1000 mg), piperine-curcuminoid combination (1515 mg), phytosome formulation (1000 mg), or the dried colloidal suspension (300 mg). Eleven blood samples were obtained over 24 h, plasma was extracted with or without deconjugation

SUBMITTER: Fanca-Berthon P 

PROVIDER: S-EPMC8245892 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature