Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation.

ABSTRACT:

Background

Disruption of DNA methylation (DNAm) is one of the key signatures of cancer, however, detailed mechanisms that alter the DNA methylome in cancer remain to be elucidated.

Methods

Here we present a novel integrative analysis framework, called MeLncTRN (Methylation mediated LncRNA Transcriptional Regulatory Network), that integrates genome-wide transcriptome, DNA methylome and copy number variation profiles, to systematically identify the epigenetically-driven lncRNA-gene regulation circuits across 18 cancer types.

Finding

We show that a significant fraction of the aberrant DNAm and gene expression landscape in cancer is associated with long noncoding RNAs (lncRNAs). We reveal distinct types of regulation between lncRNA modulators and target genes that are ope

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8245911 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature