Clp is a "busy" transcription factor in the bacterial warrior, Lysobacter enzymogenes.

ABSTRACT: Cyclic AMP receptor protein (CRP) is a well-characterized group of global transcription factors in bacteria. They are known to regulate numerous cellular processes by binding DNA and/or cAMP (a ligand called bacterial second messenger) to control target gene expression. Gram-negative Lysobacter enzymogenes is a soilborne, plant-beneficial bacterium without flagella that can fight against filamentous fungi and oomycete. Driven by the type IV pilus (T4P) system, this bacterium moves to nearby pathogens and uses a "mobile-attack" antifungal strategy to kill them via heat-stable antifungal factor (HSAF) and abundant lyases. This strategy is controlled by a unique "busy" transcription factor Clp, which is a CRP-like protein that is inactivated by binding of c-di-GMP, another ubiquitous s

SUBMITTER: Xu K 

PROVIDER: S-EPMC8246147 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature