Nucleotide polymorphism in ARDS outcome: a whole exome sequencing association study.

ABSTRACT:

Background

Genetic locus were identified associated with acute respiratory distress syndrome (ARDS). Our goal was to explore the associations between genetic variants and ARDS outcome, as well as subphenotypes.

Methods

This was a single-center, prospective observational trial enrolling adult ARDS patients. After baseline data were collected, blood samples were drawn to perform whole exome sequencing, single nucleotide polymorphism (SNP)/insertion-deletion to explore the quantitative and functional associations between genetic variants and ICU outcome, clinical subphenotypes. Then the lung injury burden (LIB), which was defined as the ratio of nonsynonymous SNP number per megabase of DNA, was used to evaluate its value in predicting ARDS outcome.

Results

A total of 105

SUBMITTER: Xu JY 

PROVIDER: S-EPMC8246154 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature