Lipid mediator lipoxin A4 and its analog BML-111 exert antitumor effects in melanoma.

ABSTRACT:

Background

LipoxinA4 (LXA4) is an anti-inflammatory lipid mediator which was recently proposed to have antitumor potential. However, the therapeutic effect of LXA4 in melanoma is still unclear. This work aimed to investigate the function of LXA4 and its analog in melanoma invasion through in vivo and in vitro experiments.

Methods

The expression of the LXA4 receptor (ALXR) was detected in melanoma tissues and A375 human melanoma cells, using benign melanocytic nevi tissues and human melanocytes as negative controls, respectively. The invasive and apoptotic abilities of A375 cells in the presence or absence of LXA4 were examined by cell invasion assay and flow cytometric analysis. Finally, mice melanoma models were established, and the antitumor effects of BML-11

SUBMITTER: Du Y 

PROVIDER: S-EPMC8246158 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature