Development and validation of a novel miRNA classifier as a prognostic signature for stage II/III colorectal cancer.

ABSTRACT:

Background

The TNM staging remains the gold standard for determining the prognosis of patients with colorectal cancer (CRC), which is inadequate at identifying the subset of high-risk stage II and III patients that have a high potential of developing tumor recurrence and may experience death. Emerging evidence indicates that not only microRNAs (miRNAs) play important functional role in CRC development but may serve as important disease biomarkers. In this study we aimed to develop a miRNA-based classifier as a prognostic signature for improving the clinical outcome of patients with stage II/III CRC.

Methods

We performed a systematic and comprehensive discovery step to identify differentially expressed miRNAs in CRC. We subsequently determined the prognostic relevance of thes

SUBMITTER: Feng J 

PROVIDER: S-EPMC8246165 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature