The HSP70 gene predicts prognosis and response to chemotherapy in epithelial ovarian cancer.

ABSTRACT:

Background

Chemotherapy resistance is an intractable problem in treating patients with epithelial ovarian cancer (EOC). Heat shock proteins (HSPs) act as apoptosis inhibitors and are highly conserved genetically. Most HSPs have strong cytoprotective effects, and their overexpression inhibits apoptosis. This has been demonstrated for HSP70. Heat shock protein 70 (HSP70) expression is abnormally upregulated in malignant cells. Furthermore, HSP70 can inhibit cell death and promote chemotherapeutic resistance. In our study, the relationship between the HSP70 gene and primary chemotherapy resistance and clinical outcome in patients with EOC was explored.

Methods

Quantitative real-time polymerase chain (qRT-PCR) was applied to determine HSP70 mes

SUBMITTER: Li XF 

PROVIDER: S-EPMC8246186 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature