The prognostic landscape of tumor-infiltrating immune cells in lung squamous cell carcinoma.

ABSTRACT:

Background

Exploring novel biomarkers and developing effective therapeutic strategies can improve the prognosis of lung squamous cell carcinoma (LUSC) in the future. The prognostic value of tumor-infiltrating immune cells (TICs) in solid tumors has been extensively studied. However, the landscape of TICs involved in the prognosis of non-small cell lung cancer (NSCLC), especially in LUSC, remains unclear and should be systematically investigated.

Methods

This retrospective study analyzed the immune-related transcriptional profiles of 490 LUSC patients from The Cancer Genome Atlas (TCGA) cohort. Using the CIBERSORT method, TICs were evaluated and examined for their association with overall survival (OS) in LUSC.

Results

Out of the 27 TICs, 14 were correlated with progno

SUBMITTER: Guo L 

PROVIDER: S-EPMC8246229 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature