Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells.

ABSTRACT:

Background

Dipeptidyl peptidase 4 (DPP-4) inhibitors have been used to treat type 2 diabetes mellitus (T2DM) via inhibition of the enzymatic activity of DPP-4 in degrading active circulating glucagon-like peptide-1. In addition to their glucose-lowering effect, DPP-4 inhibitors have pleiotropic effects. Cellular senescence regarded as important pathophysiological mechanism underlying many degenerative diseases, including atherosclerosis. This study was performed to examine whether the DPP-4 inhibitor, anagliptin, can directly protect against stress-induced accelerated senescence (SIAS) of vascular endothelial cells, regardless of changes in ambient glucose level.

Methods

Cultured human umbilical vein endothelial cells (HUVECs) were exposed to various concentrations of H

SUBMITTER: Kang SM 

PROVIDER: S-EPMC8246235 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature