Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells.

ABSTRACT:

Background

Heat shock proteins (HSPs) are molecular chaperones that protect cells against cellular stresses or injury. However, it has been increasingly recognized that they also play crucial roles in regulating fundamental cellular processes. HSP20 has been implicated in cell proliferation, but conflicting studies have shown that it can either promote or suppress proliferation. The underlying mechanisms by which HSP20 regulates cell proliferation and pluripotency remain unexplored. While the effect of HSP20 on cell proliferation has been recognized, its role in inducing pluripotency in human-induced pluripotent stem cells (iPSCs) has not been addressed.

Aim

To evaluate the efficacy of HSP20 overexpression in human iPSCs and evaluate the ability to promote cell proliferation

SUBMITTER: Ullah M 

PROVIDER: S-EPMC8246253 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature