Postnatal alcohol exposure and adolescent exercise have opposite effects on cerebellar microglia in rat.

ABSTRACT: Developmental alcohol exposure results in altered neuroimmune function in both humans and rodents. Given the critical role for the principle neuroimmune cell, microglia, in maintaining synaptic form and function, microglial dysfunction in the cerebellum may be an important mechanism underlying the aberrant cerebellar connectivity observed in rodent models of fetal alcohol spectrum disorders. Using an established rodent model of alcohol exposure during human third-trimester fetal development, we examine the cerebellum of male and female Long Evans rats to determine the impact of early postnatal alcohol exposure on cerebellar microglia, and the potential therapeutic effects of an adolescent intervention consisting of voluntary exercise (running). All cerebelli were examined at postnatal day

SUBMITTER: Gursky ZH 

PROVIDER: S-EPMC8246316 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature