Sex differences in type and occurrence of adverse reactions to opioid analgesics: a retrospective cohort study.

ABSTRACT:

Objectives

Sex as a biological variable affects response to opioids. However, few reports describe the prevalence of specific adverse reactions to commonly prescribed opioids in men and women separately. A large cohort was used to investigate sex differences in type and occurrence of adverse reactions associated with use of codeine, tramadol, oxycodone and hydrocodone.

Design

Retrospective cohort study.

Setting

Participants in the Right Drug, Right Dose, Right Time (RIGHT) Study.

Participants

The medical records of 8457 participants in the RIGHT Study who received an opioid prescription between 1 January 2004 and 31 December 2017 were reviewed 61% women, 94% white, median age (Q1-Q3)=58 (47-66).

Primary and secondary outcome measures

Adverse reactions in

SUBMITTER: Lopes GS 

PROVIDER: S-EPMC8246359 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature