TGM4: an immunogenic prostate-restricted antigen.

ABSTRACT:

Background

Prostate cancer is the second leading cause of cancer-related death in men in the USA; death occurs when patients progress to metastatic castration-resistant prostate cancer (CRPC). Although immunotherapy with the Food and Drug Administration-approved vaccine sipuleucel-T, which targets prostatic acid phosphatase (PAP), extends survival for 2-4 months, the identification of new immunogenic tumor-associated antigens (TAAs) continues to be an unmet need.

Methods

We evaluated the differential expression profile of castration-resistant prostate epithelial cells that give rise to CRPC from mice following an androgen deprivation/repletion cycle. The expression levels of a set of androgen-responsive genes were further evaluated in prostate, brain, colon, liver, lung, ski

SUBMITTER: Lopez-Bujanda ZA 

PROVIDER: S-EPMC8246381 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature