The burden of respiratory syncytial virus infections among children with sickle cell disease.

ABSTRACT:

Background

Although respiratory syncytial virus (RSV) is the leading cause of pediatric lower respiratory tract infections, the burden of RSV in children with sickle cell disease (SCD) is unknown.

Methods

We conducted a retrospective, nested, case-control study of children with SCD <18 years who had respiratory viral panels (RVPs) performed at Children's Healthcare of Atlanta from 2012 to 2019. We abstracted the medical records to describe the demographics, clinical features, and outcomes of children who tested positive for RSV (cases) versus children who tested negative (controls). We calculated the annual incidence of RSV and related hospitalization rates with 95% confidence intervals (CIs) and used multivariate logistic regression to evaluate associations.

Results

SUBMITTER: Rostad CA 

PROVIDER: S-EPMC8246443 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature