Frequency of myelin oligodendrocyte glycoprotein antibodies in a large cohort of neurological patients.

ABSTRACT:

Background

Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOG-AD) is recognized as a distinct nosological entity. IgG antibodies against MOG (MOG-Ab) overlap with neuromyelitis optica spectrum disorders (NMOSD) phenotype in adults. However, an increasing number of clinical phenotypes have been reported to be associated with MOG-Ab.

Objective

To investigate the seroprevalence of MOG-Ab under consideration of demographics, disease entities and time course in a large cohort of unselected neurological patients.

Methods

Blood samples of 2.107 consecutive adult neurologic patients admitted to our department between 2016-2017 were tested for MOG-Ab using a cell-based assay. MOG-Ab persistence was analyzed in follow-up samples. External validation was performed i

SUBMITTER: Held F 

PROVIDER: S-EPMC8246507 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature