A high molecular weight hyaluronic acid biphasic dispersion as potential therapeutics for interstitial cystitis.

ABSTRACT: Interstitial cystitis (IC) is a progressive bladder disease characterized by increased urothelial permeability, inflammation of the bladder with abdominal pain. While there is no consensus on the etiology of the disease, it was believed that restoring the barrier between urinary solutes and (GAG) urothelium would interrupt the progression of this disease. Currently, several treatment options include intravesical delivery of hyaluronic acid (HA) and/or chondroitin sulfate solutions, through a catheter to restore the urothelial barrier, but have shown limited success in preclinical, clinical trials. Herein we report for the first time successful engineering and characterization of biphasic system developed by combining cross-linked hyaluronic acid and naïve HA solution to decrease inflammati

SUBMITTER: Rooney PR 

PROVIDER: S-EPMC8246519 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature