Dosing of factor VIII concentrate by ideal body weight is more accurate in overweight and obese haemophilia A patients.

ABSTRACT:

Aims

Under- and, especially, overdosing of replacement therapy in haemophilia A patients may be prevented by application of other morphometric variables than body weight (BW) to dose factor VIII (FVIII) concentrates. Therefore, we aimed to investigate which morphometric variables best describe interindividual variability (IIV) of FVIII concentrate pharmacokinetic (PK) parameters.

Methods

PK profiling was performed by measuring 3 FVIII levels after a standardized dose of 50 IU kg^-1 FVIII concentrate. A population PK model was constructed, in which IIV for clearance (CL) and central volume of distribution (V1) was quantified. Relationships between CL, V1 and 5 morphometric variables (BW, ideal BW [IBW], lean BW, adjusted BW, and body mass index [BMI]) were evaluated

SUBMITTER: van Moort I 

PROVIDER: S-EPMC8246536 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature