Common features of aging fail to occur in Drosophila raised without a bacterial microbiome.

ABSTRACT: Lifespan is limited both by intrinsic decline in vigor with age and by accumulation of external insults. There exists a general picture of the deficits of aging, one that is reflected in a pattern of age-correlated changes in gene expression conserved across species. Here, however, by comparing gene expression profiling of Drosophila raised either conventionally, or free of bacteria, we show that ∼70% of these conserved, age-associated changes in gene expression fail to occur in germ-free flies. Among the processes that fail to show time-dependent change under germ-free conditions are two aging features that are observed across phylogeny, declining expression of stress response genes and increasing expression of innate immune genes. These comprise adaptive strategies the organism us

SUBMITTER: Shukla AK 

PROVIDER: S-EPMC8246586 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature