Ontology highlight
ABSTRACT:
SUBMITTER: Shadrach JL
PROVIDER: S-EPMC8246596 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Shadrach Jennifer L JL Stansberry Wesley M WM Milen Allison M AM Ives Rachel E RE Fogarty Elizabeth A EA Antonellis Anthony A Pierchala Brian A BA
iScience 20210608 7
The neuromuscular junction is a synapse critical for muscle strength and coordinated motor function. Unlike CNS injuries, motor neurons mount robust regenerative responses after peripheral nerve injuries. Conversely, motor neurons selectively degenerate in diseases such as amyotrophic lateral sclerosis (ALS). To assess how these insults affect motor neurons <i>in vivo</i>, we performed ribosomal profiling of mouse motor neurons. Motor neuron-specific transcripts were isolated from spinal cords f ...[more]