Association of folate intake and colorectal cancer risk in the postfortification era in US women.

ABSTRACT:

Background

Folate may play a preventive role in the early stages of colorectal carcinogenesis, but long latencies may be needed to observe a reduction in colorectal cancer (CRC) incidence. In addition, concerns have been raised about the potential for cancer promotion with excessive folate intake, especially after the mandatory folic acid fortification in the United States in 1998.

Objective

We aimed to examine the association between folate intake in different chemical forms and CRC risk, especially in the postfortification era in the United States.

Design

We prospectively followed 86,320 women from the Nurses' Health Study (1980-2016). Folate intake was collected by validated food frequency questionnaires. CRC was self reported and confirmed by review of medical rec

SUBMITTER: Wang F 

PROVIDER: S-EPMC8246607 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature