Arterial stiffening acts synergistically with APOE genotype and AD biomarker status to influence memory in older adults without dementia.

ABSTRACT:

Background

Arterial stiffening has emerged as an important risk factor for Alzheimer's disease (AD) and related dementias. Carotid-femoral pulse wave velocity has been proposed as a non-invasive and reproducible method to assess arterial stiffness. However, the association of pulse wave velocity with performance across multiple cognitive domains as well as interactions with in vivo AD biomarkers and apolipoprotein E (APOE) genotype has received limited study.

Method

We studied 193 older adult volunteers (167 with normal cognition and 26 with mild cognitive impairment) who underwent comprehensive medical and neuropsychological evaluation at the University of California, San Diego Alzheimer's Disease Research Center. Cerebrospinal fluid (CSF) biomarkers were available on 123 p

SUBMITTER: Bangen KJ 

PROVIDER: S-EPMC8246656 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature