Severe pantothenic acid deficiency induces alterations in the intestinal mucosal proteome of starter Pekin ducks.

ABSTRACT:

Background

Pantothenic acid deficiency (PAD) results in growth depression and intestinal hypofunction of animals. However, the underlying molecular mechanisms remain to be elucidated. Mucosal proteome might reflect dietary influences on physiological processes.

Results

A total of 128 white Pekin ducks of one-day-old were randomly assigned to two groups, fed either a PAD or a pantothenic acid adequate (control, CON) diet. After a 16-day feeding period, two ducks from each replicate were sampled to measure plasma parameters, intestinal morphology, and mucosal proteome. Compared to the CON group, high mortality, growth retardation, fasting hypoglycemia, reduced plasma insulin, and oxidative stress were observed in the PAD group. Furthermore, PAD induced morphological alteration

SUBMITTER: Tang J 

PROVIDER: S-EPMC8246668 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature