Simple, Axial Ligand-Mediated Route to Water-Soluble Iridium Corroles.

ABSTRACT: The synthesis and purification of water-soluble porphyrin-type compounds for photodynamic therapy and other medical applications is often a tedious exercise. Here, we have investigated the simple stratagem of adding a water-soluble axial ligand to the standard protocol for iridium insertion into simple meso-triarylcorroles. Early results showed that six-coordinate Ir[TpXPC](dna)₂ derivatives, in which TpXPC = tris(para-X-phenyl)corrole (X = CF₃, CN, H, and OMe) and dna = dinicotinic acid, are highly water-soluble. In the end, however, all axially nitrogen-ligated complexes proved unstable with respect to chromatographic purification and storage. Five-coordinate water-soluble phosphine adducts, fortunately, proved a great improvement. From t

SUBMITTER: Thomassen IK 

PROVIDER: S-EPMC8246702 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature