Microbial and transcriptional differences elucidate atopic dermatitis heterogeneity across skin sites.

ABSTRACT: It is well established that different sites in healthy human skin are colonized by distinct microbial communities due to different physiological conditions. However, few studies have explored microbial heterogeneity between skin sites in diseased skin, such as atopic dermatitis (AD) lesions. To address this issue, we carried out deep analysis of the microbiome and transcriptome in the skin of a large cohort of AD patients and healthy volunteers, comparing two physiologically different sites: upper back and posterior thigh. Microbiome samples and biopsies were obtained from both lesional and nonlesional skin to identify changes related to the disease process. Transcriptome analysis revealed distinct disease-related gene expression profiles depending on anatomical location, with keratinizati

SUBMITTER: Ottman N 

PROVIDER: S-EPMC8246754 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature