Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a secondary analysis of the PITCHES trial.

ABSTRACT:

Objective

To evaluate whether a particular group of women with intrahepatic cholestasis of pregnancy (ICP), based on their presenting characteristics, would benefit from treatment with ursodeoxycholic acid (UDCA).

Design

Secondary analysis of the PITCHES trial (ISRCTN91918806).

Setting

United Kingdom.

Population or sample

527 women with ICP.

Methods

Subgroup analyses were performed to determine whether baseline bile acid concentrations or baseline itch scores moderated a woman's response to treatment with UDCA.

Main outcome measures

Bile acid concentration and itch score.

Results

In women with baseline bile acid concentrations less than 40 μmol/l, treatment with UDCA resulted in increased post-randomisation bile acid concentrations (geometr

SUBMITTER: Fleminger J 

PROVIDER: S-EPMC8246759 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature