Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers.
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ABSTRACT:
SUBMITTER: Isnard S
PROVIDER: S-EPMC8246824 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
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Anti-cytomegalovirus Immunoglobulin G Is Linked to CD4 T-cell Count Decay in Human Immunodeficiency Virus (HIV) Elite Controllers.
Isnard Stephane S Ramendra Rayoun R Lin John J Kant Sanket S Fombuena Brandon B Ouyang Jing J Peng Xiaorong X El Far Mohamed M Tremblay Cécile C Bernard Nicole F NF Routy Jean-Pierre JP
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20210701 1
Elite controllers (ECs) are people living with human immunodeficiency virus (HIV) who spontaneously control viral replication without antiretroviral therapy. We observed that elevated anti-cytomegalovirus (CMV) immunoglobulin G (IgG) levels correlated with annual CD4 T-cell count decay in ECs independently of age, sex, and human leukocyte antigen (HLA) type. Elevated anti-CMV titers may favor disease progression in ECs. ...[more]
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2022-04-22 | PXD027749 | Pride