Timing of Aspirin Use in Colorectal Cancer Chemoprevention: A Prospective Cohort Study.

ABSTRACT:

Background

Prior epidemiological and intervention studies have not been able to separate independent effects of dose, timing, and duration of aspirin use in colorectal cancer (CRC) chemoprevention. We examined aspirin-based CRC chemoprevention according to timing in the Nurses' Health Study and Health Professionals Follow-Up Study.

Methods

The exposures include cumulative average dose and total duration of aspirin use in more than 10 years before follow-up started (remote period) and in the immediate 10 years before follow-up started (recent period). Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for exposures and CRC risk.

Results

Aspirin use of longer than 10 years before follow-up started (HR = 0.88, 95% CI = 0.83 to 0.94) p

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8246825 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature