The long-term effect of prenatal progesterone treatment on child development, behaviour and health: a systematic review.

ABSTRACT:

Background

Progesterone is widely used in prenatal care. However, long-term effects of prenatal progesterone treatment on child development are unclear.

Objectives

To evaluate long-term outcomes in children after prenatal progesterone treatment.

Search strategy

MEDLINE, Embase and Cochrane Central Register of Controlled Trials from inception to 24 May 2020.

Selection criteria

Randomised controlled trials (RCTs) reporting outcomes in children born to women who received progesterone treatment (compared with placebo or another intervention) during any trimester in pregnancy.

Data collection and analysis

Two authors independently selected and extracted data. We used the Cochrane Risk of Bias tool for randomised trials and Quality In Prognosis Studies.

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SUBMITTER: Simons NE 

PROVIDER: S-EPMC8246867 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature