Exploring novel systemic biomarker approaches in grass-pollen sublingual immunotherapy using omics.

ABSTRACT:

Background

Sublingual allergen-specific immunotherapy (SLIT) intervention improves the control of grass pollen allergy by maintaining allergen tolerance after cessation. Despite its widespread use, little is known about systemic effects and kinetics associated to SLIT, as well as the influence of the patient sensitization phenotype (Mono- or Poly-sensitized). In this quest, omics sciences could help to gain new insights to understand SLIT effects.

Methods

47 grass-pollen-allergic patients were enrolled in a double-blind, placebo-controlled, multicenter trial using GRAZAX® during 2 years. Immunological assays (sIgE, sIgG4, and ISAC) were carried out to 31 patients who finished the trial. Additionally, serum and PBMCs samples were analyzed by metabolomics and transcriptomics,

SUBMITTER: Barker-Tejeda TC 

PROVIDER: S-EPMC8246889 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature