A biologically constrained spiking neural network model of the primate basal ganglia with overlapping pathways exhibits action selection.

ABSTRACT: Action selection has been hypothesized to be a key function of the basal ganglia, yet the nuclei involved, their interactions and the importance of the direct/indirect pathway segregation in such process remain debated. Here, we design a spiking computational model of the monkey basal ganglia derived from a previously published population model, initially parameterized to reproduce electrophysiological activity at rest and to embody as much quantitative anatomical data as possible. As a particular feature, both models exhibit the strong overlap between the direct and indirect pathways that has been documented in non-human primates. Here, we first show how the translation from a population to an individual neuron model was achieved, with the addition of a minimal number of parameters. We th

SUBMITTER: Girard B 

PROVIDER: S-EPMC8246891 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature