The Rostock International Parkinson's Disease (ROPAD) Study: Protocol and Initial Findings.

ABSTRACT:

Background

Genetic stratification of Parkinson's disease (PD) patients facilitates gene-tailored research studies and clinical trials. The objective of this study was to describe the design of and the initial data from the Rostock International Parkinson's Disease (ROPAD) study, an epidemiological observational study aiming to genetically characterize ~10,000 participants.

Methods

Recruitment criteria included (1) clinical diagnosis of PD, (2) relative of participant with a reportable LRRK2 variant, or (3) North African Berber or Ashkenazi Jew. DNA analysis involved up to 3 successive steps: (1) variant (LRRK2) and gene (GBA) screening, (2) panel sequencing of 68 PD-linked genes, and (3) genome sequencing.

Results

Initial data based on the first 1360 participants indi

SUBMITTER: Skrahina V 

PROVIDER: S-EPMC8246975 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature