Genome-wide search for genes affecting the age at diagnosis of type 1 diabetes.

ABSTRACT:

Background

Type 1 diabetes (T1D) is an autoimmune disease affecting individuals in the early years of life. Although previous studies have identified genetic loci influencing T1D diagnosis age, these studies did not investigate the genome with high resolution.

Objective and methods

We performed a genome-wide meta-analysis for age at diagnosis with cohorts from Finland (Finnish Diabetic Nephropathy Study), the United Kingdom (UK Genetic Resource Investigating Diabetes) and Sardinia. Through SNP associations, transcriptome-wide association analysis linked T1D diagnosis age and gene expression.

Results

We identified two chromosomal regions associated with T1D diagnosis age: multiple independent variants in the HLA region on chromosome 6 and a locus on chromosome 17q12. W

SUBMITTER: Syreeni A 

PROVIDER: S-EPMC8247053 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature