Extended infusion of rituximab combined with steroids is effective in inducing remission and reducing relapse in adult minimal change disease.

ABSTRACT:

Background

Minimal change disease is a common cause of nephrotic syndrome in adults. Higher relapse rate put patients at risk of steroids toxicity due to long-term exposure. Rituximab has been suggested to maintain long time remission and withdraw steroids and other immunosuppressants with fewer adverse events. However, optimal dose and dosing interval have not been explored.

Methods

Twenty-five patients were enrolled from 2017-10 to 2020-03 in Nanfang Hospital in China. Clinical and biological data were extracted from medical records and laboratory databases. Therapy composed of 375mg/m² rituximab once three weeks for 3 dose and corticosteroid was applied. Complete remission was defined as reduction of proteinuria to 0.3g/d. Remission rate, relapse rate, steroids

SUBMITTER: Liu D 

PROVIDER: S-EPMC8247102 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature