Defining the resilience of the human salivary microbiota by a 520-day longitudinal study in a confined environment: the Mars500 mission.

ABSTRACT:

Background

The human microbiota plays several roles in health and disease but is often difficult to determine which part is in intimate relationships with the host vs. the occasional presence. During the Mars500 mission, six crewmembers lived completely isolated from the outer world for 520 days following standardized diet regimes. The mission constitutes the first spaceflight simulation to Mars and was a unique experiment to determine, in a longitudinal study design, the composition and importance of the resident vs. a more variable microbiota-the fraction of the human microbiota that changes in time and according to environmental conditions-in humans.

Methods

Here, we report the characterization of the salivary microbiota from 88 samples taken during and after Mars500 miss

SUBMITTER: Bacci G 

PROVIDER: S-EPMC8247138 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature